Journal: Bioorganic & medicinal chemistry letters

Article Title: Photoactivated 2,3-Distyrylindoles Kill Multi-Drug Resistant Bacteria

doi: 10.1016/j.bmcl.2018.04.001

Figure Lengend Snippet: Compound 1 is effective against a variety of drug resistant Gram-negative bacterial strains in the presence of PME and light. A. A. baumannii (ATCC BAA 1797). B. P. aeruginosa (ATCC BAA-2114). C. E. coli (ATCC 29522) D. Klebsiella pneumoniae, CRE (ATCC BAA-2146). The data are derived from a single experiment performed in 3 replicates and serve as an example of 3 independent experiments producing similar results. The stars represent no observable colonies.

Article Snippet: C. E. coli (ATCC 29522) D. Klebsiella pneumoniae, CRE (ATCC BAA-2146).

Techniques: Derivative Assay

Journal: Acta Pharmaceutica Sinica. B

Article Title: Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

doi: 10.1016/j.apsb.2023.03.002

Figure Lengend Snippet: (A) The effect of 33a on survival rates of mice infected by E. coli ATCC 2469 via intravenous route. (B) Synergism screening on combinations of 33a and β -lactamase inhibitors. (C) In vivo synergistic antibacterial effect of 33a in combination with avibactam against K. pneumoniae ATCC BAA2146.

Article Snippet: K. pneumoniae ATCC BAA2146 ESBL (+), NDM(+) , 2 , 8 , 128 , 0.5 , 0.5 , 0.50 , 0.50.

Techniques: Infection, In Vivo

Journal: Acta Pharmaceutica Sinica. B

Article Title: Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

doi: 10.1016/j.apsb.2023.03.002

Figure Lengend Snippet: Antibacterial activities of compounds 33a alone and in combination with avibactam against MDR Gram-negative bacteria strains (MIC a ).

Article Snippet: K. pneumoniae ATCC BAA2146 ESBL (+), NDM(+) , 2 , 8 , 128 , 0.5 , 0.5 , 0.50 , 0.50.

Techniques: Bacteria

Journal: Acta Pharmaceutica Sinica. B

Article Title: Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

doi: 10.1016/j.apsb.2023.03.002

Figure Lengend Snippet: (A) Schematic diagram of competitive protein fishing process. (B) Fluorescent gel of K. pneumoniae ATCC BAA2146 proteome after treatment with or without 1 or 33a (500 μmol/L), following incubation with 34 or 35 (50 μmol/L). (C–F) Fluorescent gel of bacterial proteome after treatment with 34 at different concentrations for 1 h (C), with 34 (25 μmol/L) for different durations (D), with 33a for different concentrations following the incubation with 34 (25 μmol/L) (E) and with 1 for different concentrations following incubation with 34 (25 μmol/L). (G–H) Fluorescent gel of K. pneumoniae 09–20 (G) and K. pneumoniae ATCC BAA2146 (H) proteome after treatment with or without 1 or 33a (500 μmol/L), following incubation with 34 (25 μmol/L). (I–K) SPR analysis between 33a and recombinant SHV-11 (I), CTX-M-15 (J) and CMY-6 (K).

Article Snippet: K. pneumoniae ATCC BAA2146 ESBL (+), NDM(+) , 2 , 8 , 128 , 0.5 , 0.5 , 0.50 , 0.50.

Techniques: Incubation, Recombinant

Journal: Antibiotics

Article Title: Anti-Bacterial Effects of Essential Oils against Uropathogenic Bacteria

doi: 10.3390/antibiotics9060358

Figure Lengend Snippet: Minimum inhibitory and bactericidal concentration (MIC/MBC) [mg/mL] of cajeput, lemongrass, tea tree, and thyme essential oils against 27 uropathogenic strains in artificial urine, determined by broth microdilution assay. Median values from three independent measurements are shown.

Article Snippet: Kp ATCC BAA2146 , bla NDM-1 , 12.5 , 50 , 25 , 50 , 6.25 , 6.25 , 25 , 50.

Techniques: Concentration Assay, Microdilution Assay